Biggest issue people from the northeast have is politeness. My room mate in the Marines is from NY, upstate, and his sense of humor has most Iowans shaking their head and preparing to toss his mangled corpse into a hog confinement, they eat everything. The other people I knew from the Boston area had issues with wait staff and hellos. Out here people check on their table routinely, if they are good wait staff. Politely asking how your doing, do you need anything. My friends from out east were just rude all the time. Leave me alone, if I want something I’ll yell, we just don’t do that hear and in a smaller town it’ll get you tossed out. Big culture shock both ways. I about got into fights saying hi to people in NY And Boston! Very different worlds. I got along better in Japan and China than I did in NY and Boston!New Jersey to Iowa? Wow - that's gonna take some getting used to! Good luck with it!
I've done the "big move" a few times. Bi-coastal stuff. East to West, West to East, then back to the West again. I highly recommend it - it can open your eyes about how other parts of the country live.
If you have the time to do it at a leisurely pace, it's fun to do it as a road trip. Some of the best memories of my life were things I stumbled into while on a long road trip - unexpected delights, so to speak.
And with your trip, you'll be passing right thru Chicago. If you've never been there, set aside a few days to check it out. Fun town - lots of history, great music, and great food!